TABLE 5

Summary of predictions of drug-drug interactions for CYP2C9

Inhibiting Drug	IC₅₀^a	f_u	Affected Drug	Predicted Magnitude of Drug Interaction							Actual Drug Interaction
Inhibiting Drug	IC₅₀^a	f_u	Affected Drug					[I] = C_sys	[I] = f_u × C_sys	[I] = C_{hep,inlet(est)}	Actual Drug Interaction	[I] = f_u × C_{hep,inlet(est)}
	μM
Cimetidine	>300	0.79	Tolbutamide	1.03	1.02	1.22	1.18	1.61
Citalopram	>300	0.20	Warfarin	1.00	1.00	1.01	1.00	1.00
Clarithromycin	>300	0.30	Tolbutamide	1.00	1.00	1.01	1.00	1.26
Dicumarol	0.21	0.0025	Tolbutamide	4.38	1.17	4.42	1.22	1.76
Diltiazem	>300	0.22	Tolbutamide	1.00	1.00	1.01	1.00	1.10
Disulfiram	0.96	0.04	Tolbutamide	1.00	1.00	4.23	2.03	0.99
Erythromycin	>300	0.16	Warfarin	1.01	1.00	1.04	1.01	1.16
Fluconazole	11	0.89	Warfarin	5.65	5.36	6.48	6.18	4.33
Fluvoxamine	6.1	0.23	Tolbutamide	1.11	1.03	2.50	1.51	1.50
Ketoconazole	5.9	0.01	Tolbutamide	1.68	1.01	2.60	1.03	1.77
Metronidazole	>300	0.89	Warfarin	1.31	1.27	1.46	1.41	1.56
Nefazodone	17	0.009	Warfarin	1.39	1.00	2.87	1.02	1.02
Paroxetine	130	0.05	Warfarin	1.00	1.00	1.01	1.00	1.07
Propranolol	>300	0.10	Tolbutamide	1.00	1.00	1.04	1.00	1.05
Ranitidine	>300	0.85	Warfarin	1.00	1.00	1.09	1.08	0.98
Roxithromycin	>300	0.14	Warfarin	1.01	1.00	1.02	1.00	1.00
Sertraline	81	0.02	Tolbutamide	1.01	1.00	1.25	1.01	1.19
Sulfaphenazole	0.28	0.32	Tolbutamide	4.52	4.46	4.52	4.47	5.00
Terbinafine	>300	0.01	Warfarin	1.01	1.00	1.02	1.00	1.03
Ticlopidine	110	0.02	Warfarin	1.06	1.00	1.66	1.01	1.01

↵ a Used a value of IC₅₀ = 1000 μM for those drugs for which the measured value was greater than 300 μM