TABLE 3

Effect of indomethacin (10 μM), SQ29548 (3 μM), and AH6809 (10 μM) on the Emax (in grams) values for phenylephrine in endothelium-denuded aortic rings

Number between parentheses indicates the number of replicates. Values are means ± S.E.M.

Drug
Control
Isocaloric
Ethanol
E max
Absent 2.16 ± 0.11 (10) 2.23 ± 0.11 (11) 2.78 ± 0.16a (6)
Indomethacin 1.98 ± 0.10 (9) 1.94 ± 0.12 (5) 2.04 ± 0.17bc (10)
SQ29548 2.02 ± 0.20 (7) 2.15 ± 0.10 (6) 2.21 ± 0.18bc (8)
AH6809 2.22 ± 0.15 (8) 2.33 ± 0.18 (6) 2.80 ± 0.21a (7)
SQ29548 + AH6809 1.89 ± 0.25 (6) 1.98 ± 0.20 (5) 2.04 ± 0.18bc (7)
Indomethacin + SQ29548
1.94 ± 0.19 (8)
1.96 ± 0.15 (8)
2.06 ± 0.14bc (9)

  • ↵ a Compared with respective control and isocaloric groups.

  • ↵ b Compared with the ethanol group in the absence of inhibitors.

  • ↵ c Compared with the ethanol group in the presence of AH6809 (p < 0.05; ANOVA).