Affinity of FMPD and olanzapine for key neuronal receptors
Receptor | FMPD Ki | Olanzapine Ki | ||||
|---|---|---|---|---|---|---|
| Mean ± S.E.M. | n | Mean ± S.E.M. | n | |||
| Human dopamine D1 | 30.3 ± 7.75 nM | 4 | 150 ± 11.0 nM | 3 | ||
| Human dopamine D2s | 6.33 ± 0.33 nM | 4 | 10.5 ± 0.22 nM | 732 | ||
| Human dopamine D3 | 79.7 ± 8.18 nM | 3 | 43.7 ± 8.95 nM | 3 | ||
| Human dopamine D4.4 | 102 ± 22.5 nM | 3 | 57.3 ± 6.3 nM | 3 | ||
| Human dopamine D5 | 54.2 ± 8.38 nM | 3 | 292 ± 68.8 nM | 3 | ||
| Rat dopamine D2 | 5.17 ± 1.9 nM | 3 | 10.8 ± 0.96 nM | 11 | ||
| Human 5-HT1A | 744 ± 123 nM | 3 | 957 ± 43.3 nM | 7 | ||
| Human 5-HT1B | 1093 ± 77.1 nM | 3 | 759 ± 71.8 nM | 7 | ||
| Human 5-HT1D | 629 ± 170 nM | 3 | 954 ± 140 nM | 7 | ||
| Human 5-HT1E | >3 μM | 3 | >2.5 μM | 7 | ||
| Human 5-HT1F | 1435 ± 928 nM | 2a | 801 ± 72.0 nM | 7 | ||
| Human 5-HT2A | 10.2 ± 2.57 nM | 6 | 7.48 ± 0.79 nM | 10 | ||
| Human 5-HT2B | 31.0 ± 12.6 nM | 6 | 11.9 ± 2.26 nM | 10 | ||
| Human 5-HT2C | 104 ± 16.9 nM | 6 | 70.2 ± 4.98 nM | 9 | ||
| Human 5-HT4B | >6 μM | 3 | >6 μM | 3 | ||
| Human 5-HT5A | >6 μM | 3 | 3395 ± 717 nM | 3 | ||
| Human 5-HT6 | 8.26 ± 1.36 nM | 7 | 10.5 ± 0.38 nM | 147 | ||
| Human 5-HT7A | 867 ± 90.5 nM | 6 | 389 ± 62.6 nM | 10 | ||
| Rat histamine H1 | 72.0 ± 3.8 nM | 3 | 4.2 ± 0.41 nM | 3 | ||
| Human histamine H1 | 30.3 ± 4.7 nM | 6 | 3.74 ± 1.29 nM | 3 | ||
| Rat α1-adrenergic | 19.9 ± 5.16 nM | 7 | 37.3 ± 3.46 nM | 6 | ||
| Human α1A-adrenergic | 101 ± 37.33 nM | 4 | 183 ± 59.9 nM | 4 | ||
| Human α1B-adrenergic | 126 ± 26.30 nM | 4 | 723 ± 191 nM | 4 | ||
| Human α1D-adrenergic | 408 ± 35.48 nM | 3 | 812 ± 85.1 nM | 3 | ||
| Rat α2-adrenergic | 295 ± 26.4 nM | 5 | 265 ± 39.2 nM | 4 | ||
| Human α2A-adrenergic | 767 ± 90.3 nM | 6 | 2027 ± 134 nM | 5 | ||
| Human α2B-adrenergic | 754 ± 82.0 nM | 6 | 591 ± 53.4 nM | 5 | ||
| Human α2C-adrenergic | 109 ± 7.94 nM | 6 | 330 ± 38.4 nM | 5 | ||
| Rat muscarinic | 59.2 ± 1.67 nM | 3 | 7.87 ± 0.90 nM | 4 | ||
| Human muscarinic M1 | 84.1 ± 30.6 nM | 3 | 149 ± 31.5 nM | 7 | ||
| Human muscarinic M2 | 206 ± 36.3 nM | 3 | 142 ± 39.5 nM | 7 | ||
| Human muscarinic M3 | 1935 ± 612 nM | 3 | 255 ± 62.5 nM | 7 | ||
| Human muscarinic M4 | 182 ± 24.9 nM | 3 | 213 ± 56.1 nM | 7 | ||
| Human muscarinic M5 | 199 ± 50.6 nM | 3 | 154 ± 44.2 nM | 7 | ||
| Human β1-adrenergic | >1 μM | 2 | >10 μM | 2 | ||
| Human β2-adrenergic | >1 μM | 2 | >10 μM | 2 | ||
↵ a Where n = 2, the variance is expressed as ± 50% of the range.