Effect of intravenous infusion of CGS 21680 (CGS) at 0.25, 0.5, and 1 μg/kg/min on MAP, RBF, and RVR in wild-type mice (n = 5)
Basal | CGS 0.25 | CGS 0.5 | CGS 1 | |
|---|---|---|---|---|
| MAP (mm Hg) | 86 ± 4 | 83 ± 4 | 76 ± 3 | 76 ± 2 |
| RBF (ml/min) | 1.53 ± 0.1 | 1.61 ± 0.1 | 1.74 ± 0.02 | 1.76 ± 0.05* |
| RVR (mm Hg min/ml) | 56 ± 3 | 51 ± 2 | 44 ± 2** | 43 ± 1** |
MAP, mean arterial blood pressure.
↵* p < 0.05, ** p < 0.01 (comparisons with basal by ANOVA with repeated measures and Bonferroni post hoc test).