Effect of compound A and B on various stimulus
Ligand (Cell, Readout) | Compound A IC50 | Compound B IC50 | |
|---|---|---|---|
| nM | |||
| Iloprost (UMR-108, cAMP) | 480 | 390 | |
| LTB4 (BLT1-CHO, Ca2+) | >10,000 | 4500 | |
| PGE2 (rat EP1-CHO, Ca2+) | >10,000 | >10,000 | |
| Sulprostone (HEL, Ca2+) | >10,000 | >10,000 | |
| PGD2 (CRTH2-L1.2, Ca2+) | >10,000 | >10,000 | |
| U46619 (K562, Ca2+) | >10,000 | >10,000 | |