Treatment | Potency | Potency Ratio (Treatment/Vehicle)a |
---|---|---|
ED50 (mg/kg) | ||
Vehicle/saline/nicotine | 1.05 (0.5—2.1) | |
Vehicle/nicotine/nicotine | 4.1 (3.4—5.3)b | 3.9 |
Nimodipine 1/nicotine/nicotine | 2.5 (1.9—3.7) | 2.4 |
Nimodipine 5/nicotine/nicotine | 1.7 (1.3—2.1) | 1.6 |
Verapamil 10/nicotine/nicotine | 1.6 (1.1—2.3) | 1.5 |
BAYK8644 0.1/nicotine/nicotine | 5.3 (4.8—5.8)b | 5.0 |
BAYK8644 0.5/nicotine/nicotine | 7.7 (6.1—8.3)b,c | 7.3 |