Effects of donitriptan, sumatriptan, and its vehicle on arterial blood gas parameters in the anesthetized rat Data are means ± S.E.M. in blood gas parameters after vehicle, donitriptan, or sumatriptan administration.
Parameter | Treatment | Initial Value | Value after Administration |
|---|---|---|---|
| PaO2 (mm Hg) | Vehicle (n = 10) | 120 ± 4 | 132 ± 6† |
| Donitriptan (2.5 μg/kg; n = 8) | 102 ± 4* | 131 ± 7† | |
| Donitriptan (10 μg/kg; n = 8) | 119 ± 5 | 122 ± 6 | |
| Donitriptan (40 μg/kg; n = 8) | 122 ± 8 | 136 ± 13 | |
| Sumatriptan (630 μg/kg; n = 8) | 116 ± 5 | 134 ± 8† | |
| PaCO2 (mm Hg) | Vehicle (n = 10) | 40.5 ± 1.0 | 39.3 ± 1.3 |
| Donitriptan (2.5 μg/kg; n = 8) | 37.8 ± 1.0* | 37.3 ± 1.0 | |
| Donitriptan (10 μg/kg; n = 8) | 39.8 ± 0.9 | 41.0 ± 2.0 | |
| Donitriptan (40 μg/kg; n = 8) | 39.8 ± 1.4 | 39.8 ± 2.3 | |
| Sumatriptan (630 μg/kg; n = 8) | 38.7 ± 1.5 | 38.4 ± 1.8 | |
| apH | Vehicle (n = 10) | 7.42 ± 0.01 | 7.45 ± 0.03 |
| Donitriptan (2.5 μg/kg; n = 8) | 7.42 ± 0.01 | 7.42 ± 0.01 | |
| Donitriptan (10 μg/kg; n = 8) | 7.42 ± 0.01 | 7.38 ± 0.02* | |
| Donitriptan (40 μg/kg; n = 8) | 7.42 ± 0.02 | 7.39 ± 0.02 | |
| Sumatriptan (630 μg/kg; n = 8) | 7.41 ± 0.02 | 7.39 ± 0.01 | |
| AOS (%) | Vehicle (n = 10) | 96.4 ± 1.0 | 97.9 ± 0.6† |
| Donitriptan (2.5 μg/kg; n = 8) | 97.6 ± 0.3 | 98.8 ± 0.2† | |
| Donitriptan (10 μg/kg; n = 8) | 97.7 ± 0.6 | 97.3 ± 0.8 | |
| Donitriptan (40 μg/kg; n = 8) | 97.8 ± 0.4 | 97.7 ± 0.7 | |
|
| Sumatriptan (630 μg/kg; n = 8) | 98.2 ± 0.3 | 98.6 ± 0.3 |