Broad Cerep screen undertaken to determine the pharmacological activity of fenobam
Target | % Control (10 μM) | Target | % Control (10 μM) |
|---|---|---|---|
| A1 (h) | 89.9 | Opiate (nonsel) | 114.8 |
| A2A (h) | 96.7 | ORL1 (h) | 101.4 |
| A3 (h) | 35.3 | PCP | 95.3 |
| α1 (nonsel) | 103.3 | P2X | 108.5 |
| α2 (nonsel) | 102.1 | P2Y | 95.8 |
| β1 (h) | 95.9 | 5-HT (nonsel) | 94.1 |
| β2 (h) | 79.0 | σ1 | 88.2 |
| AT1 (h) | 91.2 | σ2 | 79.2 |
| AT2 (h) | 109.6 | Glucocorticoid (h) | 96.7 |
| GABAA-BZD | 97.6 | Estrogen (h) | 100.2 |
| B1 | 108.5 | Progesterone (h) | 105.8 |
| B2 (h) | 102.1 | Androgen (h) | 108.0 |
| CB1 (h) | 95.0 | TRH | 90.6 |
| CB2 (h) | 100.5 | V1 | 103.7 |
| CCKA (h) | 112.8 | V2 (h) | 109.4 |
| CCKB (h) | 84.8 | Ca2+ L channel (DHP) | 96.7 |
| CRF1 | 106.9 | Ca2+ L channel (dilt) | 104.6 |
| D1 (h) | 100.0 | Ca2+ L channel (verap) | 150.9 |
| D2 (h) | 95.3 | K+ ATP channel | 136 |
| D3 (h) | 100.6 | K+ V channel | 103.6 |
| D4.4 (h) | 86.7 | SK+ Ca2+ channel | 97.9 |
| ETA (h) | 93.3 | Na+ channel | 88.9 |
| ETB (h) | 85.1 | Cl– channel | 103.7 |
| GABA (nonsel) | 107.5 | ADO transporter | 99.6 |
| AMPA | 93.1 | NE transporter (h) | 99.9 |
| Kainate | 103.2 | DA transporter (h) | 98.2 |
| NMDA | 91.9 | GABA transporter | 104.7 |
| Glycine (strych-sens) | 126.2 | Choline transporter | 81.4 |
| Glycine (strych-insens) | 104.1 | 5-HT transporter (h) | 101.2 |
| H1 | 89.9 | PDE I | 100.3 |
| H2 | 97.6 | PDE II (h) | 99.1 |
| H3 | 89.8 | PDE III (h) | 95.9 |
| I1 | 83.2 | PDE IV (h) | 93.4 |
| I2 | 66.3 | PDE V (h) | 106.3 |
| LTB4 (h) | 99.0 | PKC | 96.0 |
| LTD4 (h) | 106.2 | COMT | 98.9 |
| MC4 (h) | 92.2 | GABA transaminase | 94.6 |
| M (nonsel) | 94.6 | Glu. decarboxylase | 105.7 |
| NK1 (h) | 102.2 | MAO-A (h) | 70.5 |
| NK2 (h) | 89.7 | PNMT | 88.9 |
| NK3 (h) | 104.1 | TH | 122.6 |
| NPY (nonsel) | 102.5 | ATPase | 97.4 |
| N (neuronal) | 119.4 | Acetylcholinesterase (h) | 98.5 |
h, human; nonsel, nonselective; NMDA, N-methyl-d-aspartate; AMPA, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; PDE, phosphodiesterase; PKC, protein kinase C; PNMT, phenylethanolamine-N-methyltransferase; MAO-A, monoamineoxidase-A; COMT, catechol-O-methyl transferase; LTB, leukotriene B; LTD, leukotriene D; NPY, neuropeptide Y; ET, endothelin; CRF, corticotrophin-releasing factor; CCK, cholecystokinin; CB, cannabinoid; 5-HT, serotonin; TRH, thyrotrophin-releasing factor; DHP, dihydropyridine; ADO, adenosine; NE, norepinephrine; DA, dopamine; TH, tyrosine hydroxylase; Dilt, diltiazem; Verap, verapamil; PCP, phencyclidine; P2X, purinergic 2X; P2Y, purinergic 2Y; BZD, benzodiazepine.