TABLE 1

[³H]fenobam and [³H]MPEP binding properties at human and rat mGlu5 Saturation binding isotherms of [³H]fenobam and [³H]MPEP were performed on membrane preparations from HEK-293 cells transiently transfected with the human and rat mGlu5 receptors as described under Materials and Methods. Values are mean ± S.E.M. of the K_d and B_max values, calculated from three independent experiments (each performed in triplicate).