TABLE 1

EC50 and Imax data derived from DA concentration-response relationships for 5-HT3A receptors in the absence and presence of anesthetics




EC50

Imax
mM % max 5-HT
Chloroform control 0.35 ± 0.02 4.6 ± 0.1
Chloroform 2 MAC 0.28 ± 0.01 31.2 ± 0.4
Halothane control 0.29 ± 0.01 4.8 ± 0.1
Halothane 2 MAC 0.42 ± 0.02 30.0 ± 0.8
Isoflurane control 0.34 ± 0.02 5.7 ± 0.3
Isoflurane 2 MAC
0.40 ± 0.03
9.5 ± 0.5