Influence of dosing time on brain fluvoxamine concentration after fluvoxamine injection at 9:00 AM or 9:00 PM Each value is the mean with S.E. of four to eight observations. Statistical analysis by two-way ANOVA. As for the effect of the dosing time, brain concentration showed no significant time-dependent change.
Hours after Drug Injection | Injection Time | ||
|---|---|---|---|
| 9:00 AM | 9:00 PM | ||
| μg/g tissue | |||
| 0.25 | 14.74 ± 3.48 | 16.51 ± 3.78 | |
| 0.5 | 13.86 ± 0.91 | 11.16 ± 1.17 | |
| 1 | 9.54 ± 1.67 | 6.41 ± 0.46 | |
| 2 | 1.89 ± 0.14 | 1.38 ± 0.14 | |
| 4 | 0.32 ± 0.01 | N.D. | |
N.D., not detected.