cAMP Accumulation | [3H]Thymidine Incorporation | [3H]Proline Incorporation | |||||||
---|---|---|---|---|---|---|---|---|---|
LL47 | LL29 | LL47 | LL29 | LL47 | LL29 | ||||
-fold stimulation | % inhibition | ||||||||
Forskolin (1 μM) | 2.2 ± 0.1 | 2.9 ± 0.2 | 79 ± 15 | 24 ± 15* | 51 ± 14 | 10 ± 9* | |||
PGE2 (1 μM) | 1.9 ± 0.1 | 2.2 ± 0.1 | 114 ± 16 | 84 ± 4* | 114 ± 18 | 57 ± 12* | |||
Isoproterenol (1 μM) | 3.2 ± 0.2 | 2.7 ± 0.3 | 105 ± 24 | 52 ± 10* | 93 ± 8 | 28 ± 9* |
↵* Significantly decreased compared with LL47 (normal) cells by t test