Changes in plasma and intrarenal ET-1, TGF-β1, and Ang II concentration after 12 weeks of treatment Data are expressed as mean ± S.E.M., n = 6 per group.
Group | ET-1 | TGF-β1 | Ang II | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Serum | Renal Tissue | Serum | Renal Tissue | Serum | Renal Tissue | ||||
| pg/ml | pg/mg | ng/ml | pg/mg | pg/ml | pg/mg | ||||
| WKY | 76.0 ± 2.9 | 2.55 ± 0.10 | 20.1 ± 0.7 | 1.40 ± 0.04 | 46.9 ± 2.2 | 4.5 ± 0.19 | |||
| SHR | 110.2 ± 3.9** | 4.43 ± 0.17** | 37.3 ± 1.1** | 2.45 ± 0.08** | 101.5 ± 3.7** | 8.6 ± 0.31** | |||
| SHR-Ipt 1 mg/kg/day | 91.1 ± 3.6## | 3.36 ± 0.12*# | 28.1 ± 0.9## | 1.98 ± 0.07*# | 100.9 ± 3.9** | 8.0 ± 0.37** | |||
| SHR-Ipt 3 mg/kg/day | 90.5 ± 2.9## | 2.96 ± 0.09## | 24.1 ± 0.9## | 1.56 ± 0.05## | 96.1 ± 3.9** | 8.3 ± 0.21** | |||
| SHR-Ipt 9 mg/kg/day | 88.9 ± 3.4## | 2.87 ± 0.10## | 23.0 ± 0.8## | 1.46 ± 0.06## | 98.3 ± 4.0** | 8.3 ± 0.27** | |||
| SHR-Ben 3 mg/kg/day | 88.0 ± 3.5## | 2.99 ± 0.12## | 23.8 ± 0.8## | 1.44 ± 0.06## | 55.5 ± 2.5## | 5.6 ± 0.22## | |||