Competitor | Ki High | Ki Low | Sites in High-Affinity State | Y5-Insensitive Sites | ||
---|---|---|---|---|---|---|
nM | % | |||||
[Leu31,Pro34]hPYY | 0.05 ± 0.02 | 4.7 ± 1.3 | 10 ± 2 | |||
hPP | 0.08 ± 0.04 | 4.2 ± 0.9 | 25 ± 3 | |||
rPP | 92 ± 14 | 56 ± 8 | ||||
GR231118 | 4.3 ± 1.5 | 243 ± 54 | 24 ± 6 | 25 ± 4 | ||
[Ala31,Aib32]pNPY | 2.5 ± 0.4 | 80 ± 12 | 81 ± 6 | |||
[hPP(1-17),Ala31,Aib32]hNPY | 0.5 ± 0.1 | 7.4 ± 2.5 | 84 ± 5 | |||
[cPP(1-7),NPY(19-23),Ala31,Aib32,Gln34]hPP | 0.1 ± 0.05 | 1.5 ± 0.3 | 75 ± 6 | |||
CGP71683A | 1.3 ± 0.2 | 89 ± 4 | 11 ± 3 | |||
JCF109 | 9.2 ± 3.5 | 85 ± 4 | 15 ± 2 | |||
CP732925 | 1.6 ± 0.4 | 81 ± 6 | 19 ± 5 | |||
CP760524 | 2.6 ± 0.8 | 83 ± 5 | 17 ± 4 | |||
CP781214 | 4.2 ± 1.3 |
| 84 ± 4 | 16 ± 4 |