Gene | Unstimulated Expression | IL-1-Stimulated Expression | ||||||
---|---|---|---|---|---|---|---|---|
No Inhibitor | 0.1 μM BMS-345541 | 1 μM BMS-345541 | 10 μM BMS-345541 | |||||
COX-2 | 1.0 ± 0.8 | 118 ± 18 | 151 ± 49 | 8 ± 2* | 0.1 ± 0.1* | |||
iNOS | 1.0 ± 0.5 | 91 ± 15 | 127 ± 27 | 21 ± 3* | 0.4 ± 0.2* | |||
MMP-1 | 1.0 ± 0.5 | 22 ± 7 | 33 ± 12 | 4 ± 2* | 0.4 ± 0.2* | |||
MMP-3 | 1.0 ± 0.4 | 1928 ± 457 | 2500 ± 710 | 107 ± 21* | 0.8 ± 0.4* | |||
MMP-13 | 1.0 ± 0.3 | 65 ± 25 | 129 ± 59 | 12 ± 4* | 0.9 ± 0.3* | |||
ADAMTS-4 | 1.0 ± 0.4 | 1.0 ± 0.2 | 1.7 ± 0.9 | 0.6 ± 0.2 | 0.5 ± 0.2 | |||
ADAMTS-5 | 1.0 ± 0.3 | 0.9 ± 0.3 | 1.4 ± 0.5 | 0.6 ± 0.1 | 1.0 ± 0.3 | |||
TIMP-1 | 1.0 ± 0.2 | 1.8 ± 0.5 | 3.3 ± 2.3 | 1.1 ± 0.1** | 0.6 ± 0.2* | |||
TIMP-3 | 1.0 ± 0.5 | 0.9 ± 0.2 | 1.3 ± 0.3 | 1.1 ± 0.1 | 0.7 ± 0.5 |