Study Day | C12h | ||||||
---|---|---|---|---|---|---|---|
2.5 mg/kg/day | 5 mg/kg/day | 10 mg/kg/day | 20 mg/kg/day | ||||
nM | |||||||
Day 0 | 128 ± 18 | 217 ± 55 | 574 ± 114 | 994 ± 174 | |||
Day 3 | 222 ± 63 | 581 ± 236 | 1467 ± 446 | 3133 ± 1583 | |||
Day 7 | 278 ± 58 | 526 ± 35 | 1369 ± 848 | 3072 ± 1300 | |||
Day 14 | 191 ± 29 | 343 ± 130 | 1065 ± 224 | 2963 ± 1583 |