TABLE 2

Serum concentrations of A-770041 in the 14-day transplantation study

Serum concentrations of A-770041 were measured as described under Materials and Methods. Data are presented as mean ± S.D. (n = 6).


Study Day

C12h
2.5 mg/kg/day
5 mg/kg/day
10 mg/kg/day
20 mg/kg/day
nM
Day 0 128 ± 18 217 ± 55 574 ± 114 994 ± 174
Day 3 222 ± 63 581 ± 236 1467 ± 446 3133 ± 1583
Day 7 278 ± 58 526 ± 35 1369 ± 848 3072 ± 1300
Day 14
191 ± 29
343 ± 130
1065 ± 224
2963 ± 1583