TABLE 1

Significant F values for all reported data




Data

Factor

F Value
Study weight Overall weight Sex F1,1586 = 1394.7, p < 0.001
Sex × genotype F2,1586 = 6.4, p < 0.002
Within sex weight Genotype Male F2,703 = 27.4, p < 0.001, female F2,709 = 27.8, p < 0.001
Age Male F15,703 = 59.6, p < 0.001
Female F15,709 = 47.9, p < 0.001
Baseline pulse alone startle amplitude and PPI Overall pulse alone startle amplitude Sex F1,1545 = 99.9, p < 0.001
Sex × genotype F2,1545 = 11.9, p < 0.001
Genotype F2,1545 = 44.5, p < 0.001
Within sex pulse alone startle amplitude Genotype Male F2,768 = 38.2, p < 0.001, female F2,711 = 9.6, p < 0.001
Overall onset latency in pulse alone trials Sex F1,769 = 28.0, p < 0.001
Within sex habituation Genotype Male F2,6922 = 184.2, p < 0.001, female F2,6412 = 38.9, p < 0.001
Trial number Male F8,6922 = 41.5, p < 0.001, female F8,6412 = 32.2, p < 0.001
Overall PPI Sex F1,4606 = 3.9, p < 0.05
Test week F11,4606 = 21.4, p < 0.001
Prepulse intensity F2,4606 = 290.7, p < 0.001
Genotype F2,4606 = 30.9, p < 0.001
Overall onset latency in prepulse/pulse trials Sex F1,2307 = 114.3, p < 0.001
Amphetamine Overall drug effects on PPI Genotype F1,342 = 10.6, p < 0.001
Prepulse intensity F2,342 = 33.7, p < 0.001
Genotype × treatment F1,342 = 10.7, p < 0.001
Haloperidol and clozapine Overall pulse alone startle Sex F1,788 = 88.0, p < 0.001
Baseline pulse alone startle amplitude in test weeks 1, 3, and 5 Genotype F2,470 = 7.4, p < 0.001
Overall PPI Sex × genotype F2,1503 = 8.3, p < 0.001
Baseline PPI in test weeks 1, 3, and 5 Genotype Male F2,730 = 13.8, p < 0.001
Test week Male F2,730 = 5.1, p < 0.005, female F2,669 = 8.9, p < 0.001
Prepulse intensity Male F2,730 = 82.2, p < 0.001, female F2,669 = 44.69, p < 0.001
Drug effects on PPI Genotype Male F2,752 = 25.9, p < 0.001
Treatment Male F2,752 = 8.3, p < 0.001, female F2,726 = 9.0, p < 0.001
Prepulse intensity Male F2,752 = 94.4, p < 0.001
Female F2,726 = 84.4, p < 0.001
Olanzapine and quetiapine Overall pulse alone startle amplitude Sex F1,649 = 32.0, p < 0.001
Baseline pulse alone startle amplitude in test weeks 1, 3, and 5 Genotype F2,389 = 9.2, p < 0.001
Drug effects on pulse alone startle amplitude Genotype F2,389 = 4.7, p < 0.01
PPI Sex F1,1981 = 6.1, p < 0.001
Baseline PPI in test weeks 1, 3, and 5 Genotype F2,1194 = 4.4, p < 0.05
Test week F2,1194 = 58.3, p < 0.001
Prepulse intensity F2,1194 = 108.4, p < 0.001
Drug effects on PPI Genotype F2,1174 = 17.0, p < 0.001
Treatment F2,1174 = 9.9, p < 0.001


Prepulse intensity
F2,1174 = 171.0, p < 0.001