Data | Factor | F Value | |
---|---|---|---|
Study weight | Overall weight | Sex | F1,1586 = 1394.7, p < 0.001 |
Sex × genotype | F2,1586 = 6.4, p < 0.002 | ||
Within sex weight | Genotype | Male F2,703 = 27.4, p < 0.001, female F2,709 = 27.8, p < 0.001 | |
Age | Male F15,703 = 59.6, p < 0.001 | ||
Female F15,709 = 47.9, p < 0.001 | |||
Baseline pulse alone startle amplitude and PPI | Overall pulse alone startle amplitude | Sex | F1,1545 = 99.9, p < 0.001 |
Sex × genotype | F2,1545 = 11.9, p < 0.001 | ||
Genotype | F2,1545 = 44.5, p < 0.001 | ||
Within sex pulse alone startle amplitude | Genotype | Male F2,768 = 38.2, p < 0.001, female F2,711 = 9.6, p < 0.001 | |
Overall onset latency in pulse alone trials | Sex | F1,769 = 28.0, p < 0.001 | |
Within sex habituation | Genotype | Male F2,6922 = 184.2, p < 0.001, female F2,6412 = 38.9, p < 0.001 | |
Trial number | Male F8,6922 = 41.5, p < 0.001, female F8,6412 = 32.2, p < 0.001 | ||
Overall PPI | Sex | F1,4606 = 3.9, p < 0.05 | |
Test week | F11,4606 = 21.4, p < 0.001 | ||
Prepulse intensity | F2,4606 = 290.7, p < 0.001 | ||
Genotype | F2,4606 = 30.9, p < 0.001 | ||
Overall onset latency in prepulse/pulse trials | Sex | F1,2307 = 114.3, p < 0.001 | |
Amphetamine | Overall drug effects on PPI | Genotype | F1,342 = 10.6, p < 0.001 |
Prepulse intensity | F2,342 = 33.7, p < 0.001 | ||
Genotype × treatment | F1,342 = 10.7, p < 0.001 | ||
Haloperidol and clozapine | Overall pulse alone startle | Sex | F1,788 = 88.0, p < 0.001 |
Baseline pulse alone startle amplitude in test weeks 1, 3, and 5 | Genotype | F2,470 = 7.4, p < 0.001 | |
Overall PPI | Sex × genotype | F2,1503 = 8.3, p < 0.001 | |
Baseline PPI in test weeks 1, 3, and 5 | Genotype | Male F2,730 = 13.8, p < 0.001 | |
Test week | Male F2,730 = 5.1, p < 0.005, female F2,669 = 8.9, p < 0.001 | ||
Prepulse intensity | Male F2,730 = 82.2, p < 0.001, female F2,669 = 44.69, p < 0.001 | ||
Drug effects on PPI | Genotype | Male F2,752 = 25.9, p < 0.001 | |
Treatment | Male F2,752 = 8.3, p < 0.001, female F2,726 = 9.0, p < 0.001 | ||
Prepulse intensity | Male F2,752 = 94.4, p < 0.001 | ||
Female F2,726 = 84.4, p < 0.001 | |||
Olanzapine and quetiapine | Overall pulse alone startle amplitude | Sex | F1,649 = 32.0, p < 0.001 |
Baseline pulse alone startle amplitude in test weeks 1, 3, and 5 | Genotype | F2,389 = 9.2, p < 0.001 | |
Drug effects on pulse alone startle amplitude | Genotype | F2,389 = 4.7, p < 0.01 | |
PPI | Sex | F1,1981 = 6.1, p < 0.001 | |
Baseline PPI in test weeks 1, 3, and 5 | Genotype | F2,1194 = 4.4, p < 0.05 | |
Test week | F2,1194 = 58.3, p < 0.001 | ||
Prepulse intensity | F2,1194 = 108.4, p < 0.001 | ||
Drug effects on PPI | Genotype | F2,1174 = 17.0, p < 0.001 | |
Treatment | F2,1174 = 9.9, p < 0.001 | ||
|
| Prepulse intensity | F2,1174 = 171.0, p < 0.001 |