Brain penetration of unbound pemetrexed in rats after i.v. bolus administration
Rat No. | AUCbrain/AUCplasma | Terminal Rate Constant Unbound Pemetrexed in ECF | ||||
|---|---|---|---|---|---|---|
| Control | Treated | Control | Treated | |||
| min–1 | ||||||
| 1 | 0.073 | 0.074 | 0.0244 | 0.0176 | ||
| 2 | 0.083 | 0.076 | 0.0179 | 0.0122 | ||
| 3 | 0.032 | 0.043 | 0.0152 | 0.0069 | ||
| 4 | 0.125 | 0.107 | 0.0075 | 0.0088 | ||
| Mean | 0.078 | 0.075 | 0.0163 | 0.0114 | ||
| S.D. | 0.038 | 0.026 | 0.0070 | 0.0047 | ||