TABLE 1

Summary of the effects of nefiracetam, galantamine, and donepezil on NMDA receptors

	Multipolar Neurons
	Nefiracetam^a	Galantamine^a	Donepezil (Low Concentration)	Donepezil (Low Concentration)
NMDA current amplitude	↑^b	↑^d	↓^f	↑
Saturating response	↑^b	No^d^,^e	↓	↑
Glycine site interaction	Yes^b	No^d
NMDA site interaction	No^b	Yes^d	No	No
PKC interaction	Yes^c	Yes^d	Yes	Yes (partial)
PKA interaction	No^c	No^d	No	No
Gi/Go interaction	No^c	No^d	No	Yes
Gs interaction	No^c	No^d	No	Yes

↵ a No effect on NMDA currents of bipolar neurons.
↵ b Moriguchi et al. (2003b).
↵ c Moriguchi et al. (2003a).
↵ d Moriguchi et al. (2004b).
↵ e No change in saturating response; NMDA dose-response curve is shifted to lower concentrations.
↵ f Potentiation at high concentrations (30-100 μM).