TABLE 2

Hemodynamics: Protocol 2 Values are reported as percentage of baseline (100%).

PreCO
Occlusion
Reperfusion
10 min
30 min
10 min
15 min
1 h
2 h
LV-Developed Pressure*
   Control 99±4 28±6 68±8 62±8 50±8
   d-myo-IP3 97±2 33±4 59±4 53±4 43±4
   Heptanol + Control 79±12 42±7 55±10 45±7 37±6
   Heptanol + d-myo-IP3 75±14 31±4 51±11 44±9 44±6
   Gap 27 + Control 87±2 36±5 75±6 62±10 58±11
   Gap 27 + d-myo-IP3 83±6 43±6 59±7 49±4 49±6
Coronary Flow†
   Control 54±4 79±5 63±6
   d-myo-IP3 59±3 79±4 60±4
   Heptanol + Control 59±4 76±6 43±4
   Heptanol + d-myo-IP3 51±6 82±11 53±6
   Gap 27 + Control 59±3 91±7 67±4
   Gap 27 + d-myo-IP3
68±11
78±8
68±7

  • ↵* p < 0.01 over time; P = 0.08 (not significant) among groups

  • ↵† p < 0.01 over time; no significant differences among groups