Correlation of BUN and CR levels with pathology results in rats after CDDP ± NAC
Long-Evans female rats were administered 10 mg/kg i.p. cisplatin ± NAC (400 mg/kg i.v.). Results were taken 3 days postcisplatin.
Treatment (Rat No.) | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Saline | NAC | ||||||||||||||
| Ears130 | Ears133 | Ears167 | Ears155 | Ears164 | Ears132 | Ears138 | K11 | ||||||||
| BUN (mg/dl) | >140 | >140 | >140 | >140 | 32 | 26 | 25 | 36 | |||||||
| CR (mg/dl) | 7.0 | 6.7 | 6.9 | 7.2 | 0.8 | 1.7 | 0.8 | 1.1 | |||||||
| % wt. lost | -26.2 | -26.8 | -30.0 | -23.8 | -7.0 | -15.4 | -3.3 | -9.8 | |||||||
| Renal tubule damage (path) | Yes | Yes | Yes | Yes | No | No | No | No | |||||||