5-HT depletion produced by MDMA and 5,7-DHT administration
As described under Materials and Methods, tissue 5-HT was determined in samples of frontal cortex and the percentage of depletion calculated relative to rats injected with vehicle.
Treatment | Percentage of Depletion ± S.D. | ||
|---|---|---|---|
| 3-Day Group (n = 5) | 2-Week Group | ||
| MDMA | 64.6 ± 7.2* | 68.4 ± 9.4* | |
| 5,7-DHT | 50.7 ± 5.6* | 84.2 ± 9.7* | |
↵* p < 0.05 when compared with control. The control 5-HT level was 358 ± 37 pg/mg tissue.