Parameter | PAH (0.1 mg/kg) | HA | ||
---|---|---|---|---|
0.1 mg/kg | 5 mg/kg | |||
AUC (% of dose/ml · min) | 24.3 ± 1.5 | 25.1 ± 1.1 | 115 ± 15* | |
t1/2β (min) | 24.5 ± 2.2 | 21.9 ± 1.3 | 73.9 ± 4.4* | |
Vd,ss (ml/kg) | 612 ± 37 | 440 ± 22 | 433 ± 41 | |
CLtot (ml/min/kg) | 21.8 ± 1.5 | 19.3 ± 0.7 | 4.57 ± 0.68* | |
CLrenal (ml/min/kg) | 20.4 ± 1.5 | 18.1 ± 0.7 | 4.24 ± 0.64* | |
fu (%) | 91.0 ± 1.6 | 47.4 ± 1.7 | 46.0 ± 1.1 | |
Excretion ratio | 9.22 | 15.7 | 3.80 |
↵* p < 0.01, significantly different from the corresponding parameter of 0.1 mg/kg HA