Inhibitory effects of the statins on the ATP-dependent uptake of TCA by hBSEP- and rBsep-expressing membrane vesicles The values are expressed as mean ± computer-calculated S.D. The log P values were estimated by Ishigami et al. (2001).
Statin | Log P | Ki Value for hBSEP | Ki Value for rBSEP | |
|---|---|---|---|---|
| μM | ||||
| Atorvastatin | 1.5 | 9.12 ± 0.82 | 7.57 ± 1.17 | |
| Cerivastatin | 2.3 | 11.4 ± 1.3 | 30.3 ± 4.1 | |
| Fluvastatin | 1.8 | 30.2 ± 4.5 | 30.7 ± 3.1 | |
| Pitavastatin | 1.5 | 25.6 ± 3.6 | 40.8 ± 4.8 | |
| Pravastatin | -0.47 | 163 ± 20 | 805 ± 97 | |
| Rosuvastatin | -0.30 | 120 ± 15 | 385 ± 59 | |
| Simvastatin acid | 1.9 | 12.7 ± 1.4 | 30.0 ± 4.0 | |
| Atorvastatin lactone | 4.2 | 13.7 ± 4.4 | 12.0 ± 5.3 | |
| Pitavastatin lactone | 4.6a | 59.9 ± 12.8 | 228 ± 48 | |
| Pravastatin lactone | 2.4 | 37.6 ± 4.5 | 260 ± 35 | |
| Simvastatin (lactone) | 4.4 | 23.1 ± 5.8 | 48.2 ± 10.4 | |
↵ a Calculated by ChemDraw version 7.0 (Chemical Drawing software; CambridgeSoft Corporation, Cambridge, MA)