Test Outcome | Drugs Tested for Pregnanolone Substitution | ||||
---|---|---|---|---|---|
Substitutiona | 3-Hydroxy pregnane and 3-hydroxy-5-reduced androstane steroids (allopregnanolone, alloTHDOC, ganaxolone, and androsterone) | Pentobarbital and midazolam | 3β-Reduced steroid (epipregnanolone, at high doses) | Ethanol (female DBA/2J only) | |
No substitution | NMDA antagonists (MK-801 and PCP) | Benzodiazepine agonist (zolpidem) | 5-HT3 agonists (SR 57727A and CPBG) | Ethanol (male DBA/2J and female C57BL/6J only) |
↵ a Greater than 80% of mean responding during the test session occurred on the pregnanolone-appropriate lever = substitution.