Binding affinities of ciclesonide, des-CIC, and fluticasone for the human glucocorticoid receptors
IC50 | Ki | nH | ||
|---|---|---|---|---|
| nM | ||||
| Test compounds | ||||
| Ciclesonide | 210 | 37 | 0.85 | |
| des-CIC | 1.75 | 0.31 | 0.506 | |
| Fluticasone | 1.35 | 0.238 | 0.446 | |
| Reference compound | ||||
| Dexamethasone | 38 | 6.7 | 0.6 | |