Summary of IC50 values of FK228 in parental and resistant cell lines in the absence and presence of 5 μM CsA (n = 3)
Cell Line | Mean IC50 ± S.D. | IC50 Decrease | ||
|---|---|---|---|---|
| Without CsA | With CsA | |||
| nM | % | |||
| HCT-15 | 378 ± 49 | 7.4 ± 1.4 | 98.0 | |
| HCT-15/FK228 | 7139 ± 813 | 11.4 ± 0.4 | 99.8 | |
| MCF7 | 1.8 ± 0.1 | 1.6 ± 0.1 | 11.1 | |
| MCF7/FK228 | 1363 ± 203 | 50.3 ± 10.6 | 96.3 | |
| IGROV1 | 2.5 ± 0.1 | 1.3 ± 0.0 | 48.0 | |
| IGROV1/FK228 | 865 ± 89 | 7.5 ± 0.3 | 99.1 | |
| K562 | 2.7 ± 0.19 | 1.9 ± 0.1 | 29.6 | |
| K562/FK228 | 4624 ± 360 | 1123 ± 79 | 75.7 | |
| K562/Dox | 2274 ± 164 | 117 ± 9.5 | 94.9 | |