Parameters that were used in the plasma concentration simulations, and the source of the experimental data
A | B | C | D | kel | Clinical Data Source | |
|---|---|---|---|---|---|---|
| min-1 | ||||||
| Atenolol | –1.97 | –0.357 | –0.780 | 0.423 | 0.00206 | Sabanathan et al., 1987 |
| Caffeine | 0.186 | –6.81 | –0.988 | –5.82 | 0.00270 | Blanchard and Sawers, 1983 |
| Chlorpromazine | 0.671 | –2.40 | –0.947 | –1.46 | 0.000951 | Dahl and Strandjord, 1977 |
| Clonidine | 0.352 | –3.82 | –0.968 | –2.86 | 0.00117 | Lowenthal et al., 1988 |
| Desipramine | 0.601 | –2.56 | –0.948 | –1.61 | 0.000697 | Rudorfer et al., 1984 |
| Diltiazem | 1.26 | –1.84 | –0.973 | –0.870 | 0.00361 | Hermann et al., 1983 |
| Hydrochlorothiazide | –3.67 | –0.590 | –0.823 | 0.233 | 0.00117 | Sabanathan et al., 1987 |
| Ibuprofen | 0.107 | –12.2 | –1.00 | –11.2 | 0.00520 | Lee et al., 1985; Oberbauer et al., 1993 |
| Imipramine | –1.75 | –0.274 | –0.662 | 0.388 | 0.000719 | Ciraulo et al., 1988 |
| Indomethacin | 0.542 | –3.17 | –0.997 | –2.17 | 0.00479 | Oberbauer et al., 1993 |
| Metoprolol | 0.406 | –3.64 | –0.980 | –2.66 | 0.00291 | Toon et al., 1988 |
| Propranolol | 0.478 | –3.29 | –0.983 | –2.310 | 0.00344 | Garceau et al., 1978 |
| Quinidine | 1.46 | –1.65 | –0.947 | –0.699 | 0.00231 | Mason et al., 1976 |
| Saquinavir | –1.21 | –0.0200 | 0.329 | –0.349 | 0.00566 | Roche Laboratories, Nutley, NJ, product information for Fortovase (saquinavir), 2001 |
| Terbutaline | –1.49 | –0.195 | –0.833 | 0.638 | 0.00394 | Borgstrom et al., 1989 |
| Timolol | 1.36 | –1.76 | –0.965 | –0.793 | 0.00324 | McGourty et al., 1985 |
| Verapamil | 1.46 | –1.91 | –1.03 | –0.881 | 0.00633 | McTavish and Sorkin, 1989 |
| Warfarin | 0.266 | –4.65 | –0.969 | –3.69 | 0.000347 |
Holford, 1986
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