TABLE 1

Competition binding affinities for the displacement of [3H]N-α-methylhistamine binding to histamine H3 receptors endogenously present in rat or human cortex (CTX) or stably expressed as the rat or human full-length form [rH3(445), or hH3(445), respectively] in C6 cells (for nomenclature, see Hancock et al., 2003)

TABLE 1
  • Data are the average of at least three determinations and are expressed as the average pKi with standard error of the mean. Average Hill slopes (nH) are given in parentheses

  • a Values significantly different compared with human cortex binding (P < 0.05)

  • b Values significantly different compared with hH3(445) binding (P < 0.05)