PS and Vp of Aβ40 at the BBB in WT and APP,PS1 transgenic mice Data are mean ± S.D. Statistical significance was indicated by *p < 0.05, **p < 0.01, and ***p < 0.001 using Student's t test.
Brain Region | 8 Weeks | 24 Weeks | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| WT | APP,PS1 | p | APP,PS1/WT | WT | APP,PS1 | p | APP,PS1/WT | |||||||
| PS (ml/g/s × 10-6) | ||||||||||||||
| Cortex | 107.3 ± 13.9 | 68.5 ± 4.9 | ** | 0.6 | 111.9 ± 6.0 | 63.4 ± 16.7 | ** | 0.5 | ||||||
| Caudate putamen | 87.1 ± 10.1 | 63.7 ± 18.0 | N.S. | 0.7 | 129.5 ± 13.4 | 46.9 ± 13.0 | *** | 0.4 | ||||||
| Hippocampus | 96.9 ± 3.7 | 60.8 ± 5.6 | ** | 0.6 | 119.6 ± 13.0 | 82.4 ± 21.7 | * | 0.7 | ||||||
| Thalamus | 120.3 ± 7.5 | 78.9 ± 15.8 | ** | 0.7 | 128.4 ± 13.4 | 67.8 ± 21.9 | *** | 0.5 | ||||||
| Brain stem | 127.0 ± 13.3 | 93.7 ± 6.9 | ** | 0.7 | 133.9 ± 13.5 | 82.4 ± 8.1 | ** | 0.6 | ||||||
| Cerebellum | 128.3 ± 14.2 | 80.5 ± 12.7 | *** | 0.6 | 135.7 ± 20.8 | 76.9 ± 19.3 | *** | 0.5 | ||||||
| Vp (μl/g) | ||||||||||||||
| Cortex | 18.6 ± 2.2 | 17.8 ± 1.6 | N.S. | 1.0 | 18.4 ± 1.6 | 21.2 ± 0.5 | N.S. | 1.1 | ||||||
| Caudate putamen | 10.9 ± 2.5 | 11.3 ± 2.9 | N.S. | 1.0 | 14.9 ± 1.2 | 11.6 ± 1.5 | N.S. | 0.8 | ||||||
| Hippocampus | 14.3 ± 1.0 | 13.9 ± 0.8 | N.S. | 1.0 | 18.0 ± 3.1 | 25.8 ± 0.9 | ** | 1.4 | ||||||
| Thalamus | 19.8 ± 2.0 | 19.5 ± 3.0 | N.S. | 1.0 | 18.9 ± 3.1 | 18.3 ± 2.1 | N.S. | 1.0 | ||||||
| Brain stem | 24.1 ± 3.8 | 24.7 ± 2.2 | N.S. | 1.0 | 22.9 ± 3.0 | 30.7 ± 6.7 | ** | 1.3 | ||||||
| Cerebellum | 23.1 ± 2.8 | 20.7 ± 1.2 | N.S. | 1.0 | 23.1 ± 1.7 | 26.7 ± 2.2 | N.S. | 1.1 | ||||||
N.S., nonsignificant, p > 0.05.