TABLE 1

Summary of studies conducted with cloned human serotonin receptors

h5-HT2A
h5-HT2B
h5-HT2Ca
h5-HT2C (VGI)b
5-HT
   EC50 (nM) (pEC50 ± S.D.) 13 (1.13 ± 0.08) 2.5 (0.39 ± 0.19) 1.2 (0.07 ± 0.18) 2.0 (0.29 ± 0.1)
   Emax (%) 100 100 100 100
PAL-287
   EC50 (nM) (pEC50 ± S.D.) 466 (2.7 ± 0.08) 40 (1.6 ± 0.2) 2.3 (0.36 ± 0.44) 102 (2.01 ± 0.20)
   Emax (%)
74
91
20
35

  • ↵ a Studies measured drug effects on phosphoinositide hydrolysis

  • ↵ b Refers to mRNA editing program. Each value is the mean ± S.D. (n = 3)