ED50 values (milligrams per kilogram) and 95% confidence limits for compounds across the four assays in mice
Locomotor Activity | Catalepsy | Ataxia | Loss of Righting | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ED50 | 95% CL | ED50 | 95% CL | ED50 | 95% CL | ED50 | 95% CL | |||||||||||||
| SKF97541 | 0.32 | 0.07 | 0.58 | 0.42 | 0.29 | 0.62 | 0.60 | 0.35 | 0.89 | 1.55 | 0.97 | 2.21 | ||||||||
| Baclofen | 8.7 | 5.5 | 13.2 | 14.7 | 8.1 | 31.9 | 16.6 | 10.8 | 24.3 | 34.2 | 21.0 | 264.7 | ||||||||
| GBL | 86.7 | 54.5 | 123.6 | 99.9 | 66.8 | 149.3 | 133.6 | 86.8 | 205.8 | 392.2 | 279.9 | 647.6 | ||||||||
| 1,4-BDL | 177.6 | N.D. | N.D. | 209.3 | N.D. | N.D. | 197.7 | 73.3 | 356.6 | 839.4 | 501.1 | 1718.6 | ||||||||
| GHBa | 220.8 | 82.9 | 383.9 | 221.0 | 157.7 | 364.3 | 584.1 | 276.3 | 1043.8 | 1702.7 | 1093.3 | 3329.5 | ||||||||
| UMB86 | 304.1 | 133.9 | 471.7 | N.D. | 318.6 | 119.4 | 525.7 | 999.1 | 668.1 | 1493.1 | ||||||||||
| UMB72 | 422.8 | 288.3 | 619.3 | N.D. | 629.5 | 435.0 | 988.4 | 1072.6 | 735.8 | 1650.8 | ||||||||||
| UMB73 | 750.7 | 514.5 | 1098.4 | N.D. | 1235.6 | 881.8 | 2037.2 | N.D. | ||||||||||||
| 3-HPA | 1441.3 | 870.3 | 2025.5 | N.D. |
|
| 1677.3 | 1125.8 | 2869.3 | N.D. |
|
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