Derived pharmacokinetic parameters of the seven model compounds and the observed brain half-lives
↵ a kout = PS · fu,brain/Vb
↵ b kel = Clp/Vp except for fluoxetine. The kel of fluoxetine was calculated from Clp, Cld, Vp, and Vsp using eq. 8
↵ c t1/2eq = ln2/(kout – kel)
↵ d t1/2eq,in = ln2/kout
↵ e Estimated visually from the BP time course in Fig. 2
↵ f Not applicable due to kout < kel