TABLE 3

Derived pharmacokinetic parameters of the seven model compounds and the observed brain half-lives

Compound	k_out ^a	k_el ^b	t_1/2eq ^c	t_1/2eq,in ^d	Obs.t_1/2eq^e
	h^-1			h
Caffeine	18	0.75	0.040	0.039	0.1
CP-141938	2.7	0.33	0.29	0.26	1
Fluoxetine	0.70	0.23	1.5	1.0	1
NFPS	0.14	0.21	N.A.^f	5.0	>24
Propranolol	5.1	0.74	0.16	0.14	0.1
Theobromine	10	0.11	0.071	0.070	0.1
Theophylline	17	0.20	0.041	0.040	0.1

↵ a k_out = PS · f_u,brain/V_b
↵ b k_el = Cl_p/V_p except for fluoxetine. The k_el of fluoxetine was calculated from Cl_p, Cl_d, V_p, and V_sp using eq. 8
↵ c t_1/2eq = ln2/(k_out – k_el)
↵ d t_1/2eq,in = ln2/k_out
↵ e Estimated visually from the BP time course in Fig. 2
↵ f Not applicable due to k_out < k_el