Effects of CP8816 and CP8863 on progesterone dependent alkaline phosphatase expression
The results are means ± S.D. Relative efficacy was estimated as 100% at 10 nM progesterone.
Test Compounds | EC50 | Relative Efficacy |
|---|---|---|
| nM | % | |
| CP8816 | 1.6 ± 0.8 | 49 ± 3 |
| CP8863 | 13 ± 3 | 57 ± 6 |
| Progesterone | 1.6 ± 0.8 | 100 |
| Promegestone | 0.46 ± 0.22 | 80 ± 6 |
| MPA | 0.19 ± 0.07 | 79 ± 6 |