TABLE 2

Comparison of rat and transgenic mice ID50 values

Species/Genotype
Brain
CSF
mg/kg
Rat 1.3 1.3
Tg2576 mousea 2.5 1.5
TgCRND8 mouseb 1.7 NA
PDAPP mouse
NA
NA

  • NA, not assayed.

  • ↵ a Calculated from Lanz et al. (2004) at 3 h.

  • ↵ b Calculated from Wong et al. (2004) after 15 days of dosing 6 h after the last dose.