TABLE 4

Curve fit parameters for agonist-stimulated calcium signaling in stable CHO cell lines expressing human 5-HT2 receptor subtypes

Data are mean ± S.E.M. from three independent experiments.



5-HT2C

5-HT2A

5-HT2B

EC50
Emax
EC50
Emax
EC50
Emax
nM % nM % nM %
WAY-162545 39 ± 16 85 ± 3 NE NE 563 ± 166 40 ± 3
WAY-163909 8 ± 3 90 ± 6 NE NE 185 ± 105 40 ± 3
WAY-163907
1651 ± 375
60 ± 6
NE
NE
47 ± 21
20 ± 6
  • NE, no effect.