Characteristics of AMPA EPSCs recorded from CA1 SR interneurons
Two subcutaneous injections of saline or nicotine were administered to rats as described under Materials and Methods. The n value represents number of neurons. All comparisons were done by Mann-Whitney U test.
Parameter | Saline | n | Nicotine | n |
|---|---|---|---|---|
| Frequency (Hz) | ||||
| Spontaneous | 0.047 ± 0.012 | 14 | 0.084 ± 0.019 | 18 |
| ACh (10 μM) | 0.062 ± 0.025 | 8 | 0.278 ± 0.075b,d | 8 |
| ACh (100 μM) | 0.218 ± 0.049a | 8 | 1.052 ± 0.201c,e | 9 |
| Peak amplitude (pA) | ||||
| Spontaneous | 16.2 ± 1.4 | 13 | 15.9 ± 0.8 | 18 |
| ACh (10 μM) | 15.2 ± 1.0 | 7 | 16.2 ± 0.9 | 7 |
| ACh (100 μM) | 19.0 ± 1.9 | 7 | 24.2 ± 2.8f | 7 |
| Rise time (ms) | ||||
| Spontaneous | 0.85 ± 0.08 | 13 | 1.08 ± 0.13 | 17 |
| ACh (10 μM) | 0.85 ± 0.11 | 7 | 1.11 ± 0.16 | 7 |
| ACh (100 μM) | 0.98 ± 0.21 | 7 | 0.97 ± 0.08 | 7 |
| Decay-time constant (ms) | ||||
| Spontaneous | 3.33 ± 0.40 | 13 | 3.95 ± 0.44 | 16 |
| ACh (10 μM) | 3.51 ± 0.37 | 7 | 4.00 ± 0.39 | 7 |
| ACh (100 μM) | 3.12 ± 0.36 | 7 | 3.07 ± 0.25 | 7 |
↵ a p < 0.001 compared with spontaneous frequency in saline group.
↵ b p < 0.01 compared with spontaneous frequency in nicotine group.
↵ c p < 0.0001 compared with spontaneous frequency in nicotine group.
↵ d p < 0.005 compared with ACh (10 μM) in saline group.
↵ e p < 0.002 compared with ACh (100 μM) in saline group.
↵ f p < 0.001 compared with spontaneous peak amplitude in nicotine group.