Agent | Basal [Ca2+]ia | Concentration | Exposure Time | n |
---|---|---|---|---|
10-min Controlb | 114 ± 5 | 24 | ||
Pertussis toxin | 104 ± 5 | 200 ng/ml | 18 h | 12 |
TMB-8 | 138 ± 9 | 100 μM | 5 min | 4 |
Thapsigargin | 184 ± 10** | 5 μM | 5 min | 4 |
EGTA | 115 ± 13 | 10 mM | 30 sec | 5 |
LY294002 | 88 ± 20 | 50 μM | 10 min | 6 |
U73343 | 100 ± 18 | 20 μM | 5 min | 4 |
U73122 | 136 ± 6 | 20 μM | 5 min | 5 |
Genistein | 113 ± 15 | 50 μM | 10 min | 6 |
NiCl2 | 134 ± 7 | 5 mM | 3 min | 5 |
GdCl3 | 98 ± 11 | 1 mM | 3 min | 6 |
Nifedipine | 132 ± 7 | 10 μM | 3 min | 6 |
Dibutyryl-cAMP | 108 ± 16 | 100 μM | 10 min | 6 |
8-Br-cGMP | 116 ± 21 | 100 μM | 10 min | 6 |
30-min Controlc | 160 ± 16** | 9 | ||
PMA | 127 ± 9 | 1 μM | 30 min | 6 |
BIM | 155 ± 16 | 1 μM | 30 min | 6 |
H89 | 140 ± 7 | 10 μM | 30 min | 7 |
KT5823 | 216 ± 18† | 10 μM | 30 min | 6 |
↵ a Values are in nanomolar concentration in the presence of 1 mM CaCl2 5 s before addition of BK.
↵ b A 10-min control was the baseline value after 10 min of stirring.
↵ c A 30-min control was the baseline value after 30 min of stirring.
↵** P < 0.01 compared with 10-min control; †P < 0.05 compared with 30-min control.