TABLE 2

Pharmacokinetic parameters of 125I-labeled antibodies and infliximab in test and control animals

t½g=a\a
t½g=b\a
Cmax
AUC0-24 h
CLb
Vz
h μg/ml h/μg/ml ml/kg/day ml/kg
125I-Labeled antibodies (test)c 10.1 37.5 11.6 96.3 77.0 71.8
125I-Labeled antibodies (control) 22.1 86.5 15.3 235 13.5 42.7
Infliximab (test) 27.7 105 37.7 546 14.0 59.2
Infliximab (control)
21.8
119
46.0
656
11.5
46.3

  • ↵ a Half-life based on mean concentration values.

  • ↵ b Clearance determined over 72 h.

  • ↵ c Data represent the infliximab and anti-infliximab immune complex.