TABLE 2

Effects of chronic WF-23 treatment on [125I]RTI-55 binding

Brain sections from control and WF-23-treated rats were assayed for [125I]RTI-55 binding as described under Materials and Methods. Data represent ROD of [125I]RTI-55-specific binding from densitometric analysis of autoradiograms and are mean values ± S.E.M. of triplicate sections of brains from six treated and six control animals.

Specific Binding of [125I]RTI-55 (ROD, % Saline)
Saline
Day 3
Day 7
Day 15
Day 21
64 ± 5 53 ± 4* 42 ± 2* 31 ± 1* 50 ± 3*
(100 ± 8%)
(72 ± 6%)
(63 ± 3%)
(62 ± 2%)
(72 ± 5%)

  • ROD, relative optical densities.

  • ↵* p ≤ 0.001, significantly different from control by Tukey-Kramer t test for multiple comparisons.