Sensitivity and maximum response (percentage of contraction or relaxation) in venous bypass conduits of diabetic and nondiabetic patients
Diabetic | Nondiabetic | |||||
|---|---|---|---|---|---|---|
| EC50 | Maximum Response | EC50 | Maximum Response | |||
| nM | nM | |||||
| Contraction (% 70 mM KCl contraction) | ||||||
| ET-1 contraction | 48 ± 11 | 167 ± 9* | 43 ± 10 | 124 ± 7 | ||
| ET-1 + PEG-SOD contraction | 63 ± 20 | 139 ± 5*,** | 27 ± 12 | 112 ± 3 | ||
| Relaxation (% 10 nM ET-1 contraction) | ||||||
| ACh relaxation | 65 ± 10 | 46 ± 6*** | 141 ± 11 | 70 ± 5 | ||
| ACh + PEG-SOD relaxation | 113 ± 13 | 68 ± 4*** | 159 ± 11 | 75 ± 4 | ||
| KCl contraction (mN) |
| 10.3 ± 1 |
| 9.8 ± 1 | ||