TABLE 2

Contractile activity of PGF2α in urinary bladder from wild-type, M2 KO, M3 KO, and M2/M3 KO mice The data were calculated from the experiments shown in Fig. 1B. Mean values ± S.E.M. are shown. The number of experiments is indicated in parentheses. Each experiment was done on urinary bladder from a different mouse.

Mouse Strain
pEC50
Emax
% KCl
Wild type (n = 4) 5.48 ± 0.036 89 ± 18
M2 KO (n = 6) 5.22 ± 0.17 86 ± 19
M3 KO (n = 10) 6.39 ± 0.092a 186 ± 14b
M2/M3 KO (n = 2)
6.60 ± 0.15c
137 ± 19

  • ↵ a Significantly different from the corresponding value for wild type (P = 7.5 × 10-6)

  • ↵ b Significantly different from the corresponding value for wild type (P = 0.0029)

  • ↵ c Significantly different from the corresponding value for wild type (P = 0.0039)