TABLE 1

Contractile activity of oxotremorine-M in urinary bladder from wild-type, M2 KO, and M3 KO mice The data were calculated from the experiments shown in Fig. 1A. Mean values ± S.E.M. are shown. The number of experiments is indicated in parentheses. Each experiment was done on urinary bladder from a different mouse.

Mouse Strain
pEC50
Emax
% KCl
Wild type (n = 6) 6.54 ± 0.041 326 ± 27
M2 KO (n = 8) 6.31 ± 0.066a 290 ± 67
M3 KO (n = 10)
6.60 ± 0.13
48 ± 5.4b

  • ↵ a Significantly different from the corresponding value for wild type (P = 0.012)

  • ↵ b Significantly different from the corresponding value for wild type (P = 4.3 × 10-6)