pD2 values for noradrenaline in the arterial vasculature of adult (16-week-old) WKY and SHR untreated or pretreated with prazosin (2 mg kg-1 per day), nifedipine (50 mg kg-1 per day), and captopril (50 mg kg-1 per day) during 10 weeks (chronic treatment from 6 to 16 weeks old) Values are expressed in milligrams of contraction (mean ± S.E.M, n = 6–10 experiments).
Untreated | Prazosin | Nifedipine | Captopril | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| WKY | SHR | WKY | SHR | WKY | SHR | WKY | SHR | |||||
| Aorta | 8.3 ± 0.1 | 8.0 ± 0.1 | 8.2 ± 0.2 | 8.3 ± 0.2 | 8.5 ± 0.1 | 8.2 ± 0.1 | 8.2 ± 0.1 | 7.9 ± 0.2 | ||||
| Iliac | 7.2 ± 0.2 | 7.0 ± 0.1 | 7.2 ± 0.3 | 7.1 ± 0.2 | 6.8 ± 0.2 | 6.8 ± 0.1 | 6.7 ± 0.3 | 6.8 ± 0.1 | ||||
| Tail | 6.3 ± 0.1 | 6.0 ± 0.1 | 6.2 ± 0.2 | 5.7 ± 0.2 | 6.3 ± 0.1 | 6.2 ± 0.1 | 6.1 ± 0.1 | 6.2 ± 0.1 | ||||
| MMA | 7.2 ± 0.2 | 6.8 ± 0.1 | 6.8 ± 0.2 | 7.1 ± 0.2 | 6.5 ± 0.3 | 6.6 ± 0.1 | 6.4 ± 0.1 | 6.6 ± 0.2 | ||||
| SMA-1 | 5.9 ± 0.1 | 5.8 ± 0.2 | 5.9 ± 0.2 | 6.1 ± 0.1 | 6.0 ± 0.1 | 6.1 ± 0.1 | 6.0 ± 0.1 | 6.0 ± 0.1 | ||||
| SMA-2 | 5.9 ± 0.2 | 6.1 ± 0.2 | 6.1 ± 0.1 | 6.0 ± 0.1 | 6.2 ± 0.1 | 6.1 ± 0.1 | 5.9 ± 0.1 | 6.1 ± 0.1 | ||||
MMA. main mesenteric artery.