Compartmental pharmacokinetic parameter estimates for rHuEPO following i.v. and s.c. administration
Parameter | Definition | Parameter Estimates | Coefficient of Variation (%) |
|---|---|---|---|
| Vc (ml/kg) | Volume of central compartment | 39.8 | <1 |
| CLlin (ml/h/kg) | Clearance described by linear elimination pathways | 3.09 | 10 |
| Km (mIU/ml) | Michaelis-Menten constant | 172 | 29 |
| Vmax (mIU/kg/h) | Elimination capacity | 2276 | 24 |
| k12 (h-1) | Distribution rate constant | 1.19 | 9 |
| k21 (h-1) | Distribution rate constant | 1.47 | 10 |
| kblood (h-1) | Transfer rate constant into blood | 0.007 | 11 |
| klymph (h-1) | Transfer rate constant into lymph | 0.17 | 1 |
| kinput (h-1) | Transfer rate constant from lymph into blood | 1.79 | 38 |
| tlag (h) | Lag time | 0.52 | 2 |
| F abs | Total fraction of the dose absorbed | 0.87 | 1 |
| F lymph | Fraction of the absorbed dose taken up via the lymph | 0.96 | <1 |
|
F
blood
| Fraction of the absorbed dose taken up via the blood | 0.04 | 10 |