Histologic Score | Relative Fibrosis Area | Relative Area of α-Smooth Muscle Actin Positive Cells | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Inflammatory Cell Infiltration | Interstitial Edema | Acinar Cell Necrosis | Hemorrhage | Fibrosis | |||||||
% | |||||||||||
Untreated (n = 5) | 2.2 ± 0.4 | 2.2 ± 0.4 | 2.4 ± 0.5 | 2.2 ± 0.8 | 2.6 ± 0.5 | ||||||
Low combination (n = 5) | 2.0 ± 0.0 | 1.6 ± 0.5 | 0.8 ± 0.4** | 2.0 ± 0.7 | 2.6 ± 0.5 | 40.2 ± 26.8** | 59.2 ± 19.1 | ||||
Medium combination (n = 5) | 1.5 ± 0.6 | 1.3 ± 1.0 | 1.0 ± 0.8* | 1.3 ± 1.0 | 1.3 ± 0.5*,# | 14.6 ± 9.1*** | 16.5 ± 5.9** | ||||
Combination (n = 5) | 0.9 ± 0.4***,## | 0.3 ± 0.5***,# | 0.4 ± 0.5*** | 0.7 ± 0.5* | 1.0 ± 0.6**,## | 28.1 ± 14.8*** | 46.9 ± 17.9 |