Against Passive Tension | Against KCl-Induced Precontraction | |
---|---|---|
Absence of inhibitors | ||
H2O | 37 ± 3 | 70 ± 2 |
Ethanol | 38 ± 3 | 73 ± 1 |
DMSO | 42 ± 4 | 70 ± 2 |
Acetic acid | 37 ± 3 | 61 ± 6 |
Cyclic nucleotide-dependent pathways | ||
SQ 22,536 | 26 ± 3 | 74 ± 3 |
H7 | 27 ± 3 | 73 ± 1 |
H89 | 38 ± 5 | 66 ± 5 |
Rp-cAMPS | 23 ± 3* | 75 ± 2 |
ODQ | 30 ± 3 | 72 ± 3 |
l-NNA | 29 ± 4 | 67 ± 3 |
Potassium channels | ||
BaCl2 | 44 ± 4 | 73 ± 2 |
Tetraethylammonium | 35 ± 6 | 69 ± 4 |
Glibenclamide | 35 ± 7 | 64 ± 2 |
Apamin | 43 ± 4 | 63 ± 2 |
Charybdotoxin | 45 ± 4 | 49 ± 2* |
Iberiotoxin | 41 ± 6 | 56 ± 1* |
Combinations | ||
SQ + ODQ | 17 ± 3* | 59 ± 3* |
SQ + charybdotoxin | 32 ± 3 | 46 ± 1* |
ODQ + charybdotoxin | 41 ± 3 | 51 ± 1* |
SQ + ODQ + charybdotoxin | 17 ± 3* | 49 ± 2* |
DMSO, dimethyl sulfoxide.
↵* P < 0.05 vs. corresponding vehicle control in a two-tailed t test or one-way analysis of variance followed by Dunnett's tests