TABLE 1

PLC and PKC, but not PKA, mediate the [³H]NE release induced by SRIF-14 + NMDA + glycine from rat hippocampal synaptosomes

SRIF-14 (1 nM), NMDA (100 μM), and glycine (1 μM) were added 8 min after the enzyme inhibitors. Enzyme inhibitors failed, on their own, to affect the basal release of [³H]NE (0.1 μM U73122 = 4.72 ± 3.56; 0.1 μM GF109203X = –3.89 ± 2.34; 0.5 μM H89 = 6.78 ± 5.43). Results are expressed as percentage of increase over basal release. Data are means ± S.E.M. from three to eight experiments run in triplicate (three superfusion chambers for each experimental condition).