Effect of CDPPB on FLIPR agonist concentration-response curves: human and rat mGluR5
Agonist | Control Agonist EC50 | EC50 Change at 1 μM CDPPB* |
|---|---|---|
| -fold | ||
| Human mGluR5a CHO cells | ||
| Glutamate | 447 ± 42 nM (3) | 9.1 |
| 3,5-DHPG | 1.6 ± 0.22 μM (3) | 8.7 |
| Quisqualate | 8.9 ± 0.6 nM (3) | 2.7 |
| Rat mGluR5 CHO cells | ||
| Glutamate | 892 ± 92 nM (3) | 6.8 |
| 3,5-DHPG | 2.65 ± 0.22 μM (3) | 6.0 |
| Quisqualate | 24 ± 0.9 nM (3) | 3.9 |