TABLE 2
IC
50
(NHE inhibition) values
NHE Inhibitor Drug
IC
50
(μM) ± S.D. (NHE Inhibition)
Relative Potency
Amiloride
50 ± 27
1
Cariporide
0.074 ± 0.072
676
Gly-C(5)-
Am
(4a)
13 ± 7
4
Leu-Phe-Gly-Gly-Gly-Gly-C(5)-
Am
(4d)
No inhibition ≤ 100 μM
<0.5